I don't care where my data and methods are: A web-service approach for distributed access to methods, data and models. In recent years cheminformatics has been enhanced with the public availability and accesibility of methods and chemical and biological data. This talk will highlight recent progress on the development of a web service based infrastructure to provide uniform and distributed access to methods, data and models in a general manner. I will focus on the use of the infrastructure to provide access to a variety of statistical methods and predictive models, highlighting a number of applications based on these services. In addition to providing access to data, it is useful to add value to current data sources. I will present a shape searchable, single conformer, 3D derivative of PubChem allowing one to retrieve similar shaped molecules in 10 to 30 sec depending on similarity cutoffs. I will discuss some approaches that will allow us to include arbitrary numbers of conformers yet still maintain reasonable query times.