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The Indiana University Biocomplexity Institute at IUB, Medical Sciences at IUB; the Center for Regenerative Biology and Medicine at IUPUI and IUB; the School of Medicine at IUPUI; the School of Science at IUPUI and the University of Notre Dame: Interdisciplinary Center for the Study of Biocomplexity
Present a Workshop
Biocomplexity IV: REGENERATIVE BIOLOGY AND MEDICINE
May 14-18, 2003
Indiana University Bloomington
Willkie Conference Center
Regenerative biology is the science
of understanding the mechanisms of natural regeneration that are used
in the animal world to replace cells, tissues and complex structures and
how these mechanisms differ from those that lead to fibrosis, or scarring.
Regenerative medicine is the application of this knowledge to enable the
regeneration of biological structures that normally do not regenerate
well. The process of regeneration requires a source of regeneration-competent
cells, the right systemic and local environmental signals, and the absence
of inhibitors of regeneration. There are four basic types of regeneration
in multicellular animals: Single cell regeneration, such as neuronal axon
re-growth; compensatory hyperplasia of differentiated cells, as seen in
liver regeneration; regeneration by reserve adult stem cells, characteristic
of a wide variety of tissues and organisms; and regeneration via stem
cells created by dedifferentiation, a mode used by amphibians to regenerate
a wide variety of complex structures. Fibrosis and regeneration have been
studied for over two centuries. But only recently, with the discovery
that many non-regenerating tissues harbor regeneration-competent cells
and that some stem cell populations appear to be developmentally plastic,
has the study of regenerative biology and medicine been given major attention.
The intent of this workshop is to bring together experts on regeneration
over a wide range of experimental systems to synthesize the current state
of our knowledge on the biology of regeneration and to assess our progress
toward the establishment of a regenerative medicine.
Organizers
David L. Stocum, IUPUI, Center for Regenerative Biology and Medicine
James A. Glazier, IUB, Biocomplexity Institute
Anton Neff, IUB, Center for Regenerative Biology and Medicine
Anthony L. Mescher, IUB, Center for Regenerative Biology and Medicine
Mark Alber, Interdisciplinary Center for the Study of Biocomplexity, University
of Notre Dame
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