Matthew W. Grow, Ph.D.

Assistant Professor of Biochemistry and Molecular Biology
Department of Biochemistry and Molecular Biology
Indiana University School of Medicine

Background
B.S., 1993, Purdue University, West Lafayette, IN, USA
Ph.D., 1999, University of Texas, Austin, TX, USA
Post Doctoral, 2000-2001, Massachusetts General Hospital, Boston, MA, USA

Research Interests

Although the cardiovascular system is the first functional system to form during embryonic development, very little is currently known about the molecular processes required for this formation. The aim of my research is to identify and better understand the genes involved in the development of the vertebrate heart and vasculature. My lab will conduct experiments primarily on the embryos of the South African Clawed Frog (Xenopus laevis), but will also exploit the genetic potential of zebrafish (Danio rerio), and Xenopus tropicalis. In addition to constructing and utilizing microarrays to study transcriptional pathways involved in cardiovascular development, this lab will continue to explore and, when possible, apply the latest advances in genomics to our ongoing research.

Selected Publications

Newman, C. S., Reecy , J ., Grow M. W., Ni, K., Boettger, T., Kessel, M., Schwartz, R. J., and Krieg, P. A., 2000. Transient cardiac expression of a tinman-family homeobox gene, XNkx2-10. Mech. Dev. 91 (1-2), 369-373.

Grow, M. W., and Krieg, P. A., 1998. Tinman function is essential for vertebrate heart development Elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. Dev. Biol 204, 187- 196.

Patterson, K D., Cleaver, O. B., Gerber, W. V., Newman, C., Grow, M., and Krieg, P. A., 1998. Homeobox genes in cardiovascular development. Current Topics in Dev. Biol. 40, 1-44.

Newman, C. S., Grow, M. W., Cleaver, O. B., Chia, F. and Krieg, P. A., 1997. Xbap, a vertebrate bagpipe-related gene is expressed in developing craniofacial structures and in the anterior gut primordium. Dev. Biol. 181, 223-233.

Zorn, A. M., Grow, M. W., Patterson, K. D., Ebersole, T. A., Chen, Q., Artzt, K., and Krieg, P. A., 1997. Remarkable sequence conservation of transcripts encoding amphibian and mammalian homologues of quaking, a KH-domain RNA-binding protein. Gene 188(2), 199-206.

More Information
Homepage: http://www.biochemistry.iupui.edu/personnel/Grow/
Grow Lab: http://cmg.iupui.edu/grow/